WP 1.2 - Prevalence Cohort The prevalence of anaphylaxis in children and adults in cohorts

Background:

Since 2001 data on all patients referred to the Allergy Centre with anaphylaxis has been stored in a database.  The frequency of Emergency Room (ER) visits in these patients after diagnosis has been established has not been evaluated. Data on the incidence and prevalence of anaphylactic reactions in the general population are lacking. Most data are based on national patient databases or registrations in emergency departments. Two unselected cohorts were established at the Allergy Center in 1995 (n=1501, age 14) and 1998 (n=562, birth cohort).

Hypothesis:

The risk of a severe reaction in a patient after diagnosis has been established depend on both the clinical sensitivity (threshold) of the patient, presence of concomitant asthma and the allergy in question, so that e.g. patients with peanut allergy and asthma are more prone to severe reactions requiring an ER visit than patient without asthma and with allergy to milk or penicillin. Anaphylactic reactions (including those requiring treatment with adrenaline) are under-diagnosed in Denmark. The prevalence and the culprit agents in the general population are unknown.

Methods:

This is a descriptive study in selected patients referred to the Allergy Centre for evaluation of anaphylaxis during the last 12 years, supplemented with an epidemiological follow-up study among unselected adolescents and adults followed prospectively for respectively 17 years and 14 years. From our patient database of anaphylaxis caused by food, drugs and insects severity of the reactions  (frequency, severity according to Sampson et al 2003, concomitant factors such as intake of drugs, infection or exercise) and number of Emergency Room visits will be evaluated. 

The lifetime prevalence of anaphylaxis, asthma, urticaria, angioedema and mastocytosis (based both on elevated s-tryptase and clinical criteria) in unselected young adults from the TOACS cohort (age 33 years) and adolescents from the DARC cohort (age 14 years) will be evaluated.

Cohort

N

Comments

Peanut

249

 

In total all foods >2000 

Hazelnut

174

Milk

121

Egg

237

Wheat (FDEIA)

60

 

NSAID

142

 

Insulin

100

 

Penicillin

1500

747 ptt in cohort

Insects

200

 

TOACS

1501

Unselected

DARC

562

Unselected

Webdesign af mira.dk